The animal respiratory amplitude is consistently apparent to polycyclic ambrosial hydrocarbons (PAHs) through assimilation of atmospheric pollutants. We advised the furnishings of three PAHs (benzo[a]pyrene, anthracene, and fluoranthene) on the airway ion transport, which is capital for lung aegis and accustomed airway function, appliance animal airway epithelia (Calu-3). These three PAHs had no cogent aftereffect on the basal circumlocute accepted (Isc). However, fluoranthene (1–100 μM) activated in the aciculate alcove potentiated Isc in acknowledgment to cAMP-related agents (isoproterenol, forskolin, and 8-bromo-cAMP). The furnishings of fluoranthene were artless by ellipticine, a PAH receptor antagonist. The fluoranthene-induced modulations of these anion transporters were counteracted by charybdotoxin (ChTx, a hIK-1 approach blocker). Fluoranthene gradually aggrandized the ChTx-sensitive K+ accepted (IK) beyond the basolateral membrane, accompanied by a abiding access in the cytosolic Ca2+concentration ([Ca2+]i). In the attendance of fluoranthene, however, a abundant beyond hIK-1-dependent IK was articular by the appliance of 8-bromo-cAMP after accessory acclivity of [Ca2+]i.