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Effect of Costunolide and Dehydrocostus Lactone on Cell Cycle

  Human bendable tissue sarcomas represent a attenuate accumulation of cancerous tumours that frequently display chemotherapeutic attrition and added metastatic abeyant afterward bootless treatment. In this study, we advised the furnishings of costunolide and dehydrocostus lactone, which accept been abandoned from Saussurea lappa application activity-guided isolation, on three bendable tissue bump corpuscle curve of assorted origins. The furnishings on corpuscle proliferation, corpuscle aeon distribution, apoptosis induction, and ABC agent announcement were analysed.


Genotoxicity assessment of Caryophyllene oxide

  Caryophyllene oxide is a biciclic sesquiterpene, occurring naturally in essential oils from various medicinal and edible plants and used as a flavouring agent. Due to its potential hazardous chemical structure, the European Food Safety Authority reported to be pending a safety assessment for this compound. Here, this flavouring agent was tested for its mutagenic effect in the Ames test and micronucleus assay. Furthermore, considering that the penetration of a substance through phospholipid bilayers is determinant for its activity, the ability of Caryophyllene oxide to be absorbed into cells was evaluated by differential scanning calorimetry (DSC) using multilamellar vesicles of dimyristoylphosphatidylcholine as a biomembrane model.