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Estimation of Costunolide and Dehydrocostus Lactone in Saussurea lappa


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  Saussurea lappa is one of the accepted Ayurvedic herb; costunolide and dehydrocostus lactones are acclaimed sesquiterpene lactones independent in abounding plants acclimated as accepted herbs, such as S. lappa, and accept been advised as abeyant candidates for the assay of assorted types of tumor.

  The present abstraction was acclimated for the altitude of costunolide and dehydrocostus lactone in S. lappa and its polyherbal formulations, adherence studies of markers and assuming of their degradants. HPLC assay was performed on Waters NOVAPAK HR C 18 cavalcade (300 mm Χ 3.9 mm i.d., 6 μm) application isocratic elution with acetonitrile and baptize (60:40% v/v).

  The arrangement curves of both analytes showed acceptable breadth aural the accustomed ambit 5-100 μg/ml. The banned of apprehension (LOD) and altitude (LOQ) were 1.5 and 4.6 μg/ml for costunolide and 1.3 and 4.0 μg/ml for dehydrocostus lactone, respectively. Acceptable after-effects were accomplished with account to repeatability (%RSD < 2.0) and accretion (99.3-101.8%). Conclusion: The adjustment was begin to be precise, accurate, specific, and was auspiciously acclimated for allegory costunolide and dehydrocostus lactone in S. lappa and its polyherbal formulations. The developed adjustment was begin to be acceptable for adherence studies of markers and assuming of their abasement products.